The Bähler laboratory studies genome regulation during cellular quiescence, ageing and stress response using fission yeast as a model system. We apply multiple genetic, computational and genome-wide approaches for systems-level understanding of regulatory networks and complex relationships between genotype, phenotype, and environment, including roles of genome variation and evolution, transcriptome regulation, and non-coding RNAs.
We are at University College London in the Department of Genetics, Evolution & Environment and associated with the UCL Cancer Institute, the UCL Genetics Institute, and the Institute of Healthy Ageing. Our research is mainly funded by a Senior Investigator Award from the Wellcome Trust, the BBSRC, a Royal Society Wolfson Research Merit Award, and the EC FP7 PhenOxiGEn project.
Selected Publications:
Marguerat S, Schmidt A, Codlin S, Chen W, Aebersold R, Bähler J (2012). Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell 151, 671-683
Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bähler J (2008). Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature 453, 1239-1243
López-Maury L, Marguerat S, Bähler J (2008). Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. Nat Rev Genet 9, 583-593
Lackner DH, Beilharz TH, Marguerat S, Mata J, Watt S, Schubert F, Preiss T, Bähler J (2007). A network of multiple regulatory layers shapes gene expression in fission yeast. Mol Cell 26, 145-155
